Development on Deaf Support Application Based on Daily Sound Classification Using Image-based Deep Learning

According to statistics, the number of hearing-impaired persons among the disabled in Korea accounts for 27% of all persons with disabilities. However, there is insufficient support for the deaf and hard of hearing's protective devices and life aids compared to the large number. In particular, the hearing impaired misses much information obtained through sound and causes inconvenience in daily life. Therefore, in this paper, we propose a method to relieve the discomfort in the daily life of the hearing impaired. It analyzes sounds that can occur frequently and must be recognized in daily life and guide them to the hearing impaired through applications and vibration bracelets. Sound analysis was learned by using deep learning by converting sounds that often occur in daily life into the Mel-Spectrogram. The sound that actually occurs is recorded through the application, and then it is identified based on the learning result. According to the identification result, predefined alarms and vibrations are provided differently so that the hearing impaired can easily recognize it. As a result of the recognition of the four major sounds occurring in real life in the experiment, the performance showed an average of 85% and an average of 80% of the classification rate for mixed sounds. It was confirmed that the proposed method can be applied to real-life through experiments. Through the proposed method, the quality of life can be improved by allowing the hearing impaired to recognize and respond to sounds that are essential in daily life

Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging

For this research article, we investigated the protective effects of enzyme-treated caviar powder extract (CV) in ultraviolet B (UVB)-irradiated hairless mice and keratinocytes by confirming moisturizing-related factors and elasticity-related factors. UVB irradiation induced wrinkle formation, dehydration, oxidative stress, and inflammation in the dorsal skin of mice; however, these were suppressed in the CV-supplemented groups in UVB-irradiated hairless mice. Furthermore, in UVB-irradiated keratinocytes, CV treatment increased the antioxidant enzyme activities and the levels of sphingomyelin and hyaluronic acid and decreased the production of pro-inflammatory cytokines and the expression of IkB-α and p65 phosphorylation. These findings indicate that CV can directly protect keratinocytes against UVB irradiation-induced oxidative stress and inflammation. Therefore, we suggest that CV can protect against UVB-induced skin photoaging. Therefore, we suggest that caviar is effective for skin health by preventing UVB-induced skin photoaging

Diphlorethohydroxycarmalol Inhibits Interleukin-6 Production by Regulating NF-κB, STAT5 and SOCS1 in Lipopolysaccharide-Stimulated RAW264.7 Cells

Diphlorethohydroxycarmalol (DPHC) is a phlorotannin compound isolated from Ishige okamuarae, a brown alga. This study was conducted to investigate the anti-inflammatory effect and action mechanism of DPHC in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. We found that DPHC strongly reduces the production of interleukin 6 (IL-6), but not that of tumor necrosis factor-alpha (TNF-α) induced by LPS. DPHC (12.5 and 100 μM) suppressed the phosphorylation and the nuclear translocation of NF-kappaB (NF-κB), a central signaling molecule in the inflammation process induced by LPS. The suppressor of cytokine signaling 1 (SOCS1) is a negative feedback regulator of Janus kinase (Jak)-signal transducer and activator of transcription (STAT) signaling. In this study, DPHC inhibited STAT5 expression and upregulated that of SOCS1 at a concentration of 100 μM. Furthermore, N-tosyl-l-phenylalanine chloromethyl ketone (TPCK) (a specific NF-κB inhibitor) and JI (a specific Jak2 inhibitor) reduced the production of IL-6, but not that of tumor necrosis factor-alpha (TNF-α) in LPS-stimulated RAW 264.7 macrophages. These findings demonstrate that DPHC inhibits IL-6 production via the downregulation of NF-κB and Jak2-STAT5 pathway and upregulation of SOCS1